Mast Cell Research
An online resource for research articles and publications on Mast Cell Activation Disease (MCAD), including news and information concerning Dr. Lawrence B. Afrin’s newly published book, ‘Never Bet Against Occam: Mast Cell Activation Disease and the Modern Epidemics of Chronic Illness and Medical Complexity.’ (2016)
‘Never Bet Against Occam:
Mast Cell Activation Disease and the Modern Epidemics of Chronic Illness and Medical Complexity’
– Lawrence B. Afrin, M.D.
“This book describes for the lay community some of the many presentations of mast cell activation disease. It also provides a general overview of the approach to the treatment of this disease and where we stand (and where we need to go) in the research of this area.”
More About The Book
Dr. Afrin earned a B.S. in computer science at Clemson University in 1984 and then an M.D. at the Medical University of South Carolina (MUSC) in 1988, where he also pursued internal medicine residency and hematology/oncology clinical and research fellowships. While on faculty at MUSC from 1995-2014, he was active in undergraduate and graduate medical education, educational and information technology administration, and practice and research in hematology/oncology and medical informatics.
Since the mid-’00s, his clinical work has increasingly focused in hematology, especially mast cell disease. In 2008 Dr. Afrin started coming to understand that a newly recognized type of mast cell disease, now called mast cell activation syndrome (MCAS), was the underlying diagnosis in many patients he was seeing who were each suffering large assortments — quite different from one patient to the next — of chronic multisystem inflammatory illnesses of unclear cause.
Dr. Afrin soon gained experience that MCAS is far more prevalent than the only mast cell disease previously known to medicine (the rare disease of mastocytosis) and that most MCAS patients, once accurately diagnosed, can eventually find significantly helpful medications targeted at the disease.