Celebrating Our 5-Year Publishing Anniversary on March 15th!

Mast Cell Research

An online resource for research articles and publications on Mast Cell Activation Disease (MCAD), including news and information concerning Dr. Lawrence B. Afrin’s newly published book, ‘Never Bet Against Occam: Mast Cell Activation Disease and the Modern Epidemics of Chronic Illness and Medical Complexity.’ (2016)

420+ 🌟🌟🌟🌟🌟 Reviews!

‘Never Bet Against Occam: Mast Cell Activation Disease and the Modern Epidemics of Chronic Illness and Medical Complexity’ by Lawrence B. Afrin, M.D.

“This book describes for the lay community some of the many presentations of mast cell activation disease. It also provides a general overview of the approach to the treatment of this disease and where we stand (and where we need to go) in the research of this area.”

Dr. Lawrence Afrin hopes this book will help people who might have, or do have, MCAS. A portion of the proceeds of purchases of this book will go to support research and education in this area. About Dr. Afrin

Lawrence B. Afrin


Dr. Afrin earned a B.S. in computer science from Clemson University in 1984 and then an M.D. at the Medical University of South Carolina (MUSC) in 1988, where he also pursued internal medicine residency and hematology/oncology clinical and research fellowships. While on the faculty at MUSC from 1995-2014, he was active in undergraduate and graduate medical education, educational and information technology administration, and practice and research in hematology/oncology and medical informatics. Since the mid-’00s, his clinical work has increasingly focused in hematology, especially mast cell disease. He joined the University of Minnesota in 2014 to further his interests in this area.

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What are Mast Cell Disorders?

Mast cell disorders are caused by the proliferation and accumulation of genetically altered mast cells and/or the inappropriate release of mast cell mediators, creating symptoms in multiple organ systems.2The two major forms of mast cell disorders are mastocytosis and mast cell activation syndromes (MCAS). Mast cell disorders can cause tremendous suffering and disability due to symptomatology from daily mast cell mediator release, and/or symptoms arising from infiltration and accumulation of mast cells in major organ systems. Although systemic mastocytosis is a rare disease,3 those suffering with MCAS have recently been increasingly recognized and diagnosed. As a result, patients with MCAS appear to represent a growing proportion of the mast cell disorder patient population.4, 5 It is important to note that the process of mast cell activation can occur in anyone, even without a mast cell disorder, as well as in patients with both mastocytosis and MCAS.6″ (source – TMS Society)

Information and Updates

The Mast Cell Research Podcast

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Mast cells are the “universal alarm cell” that starts the inflammatory cascade. They can be triggered by infection, allergens, environmental factors like pollution, or even emotional stress.”
Dr. Theo
AKA – “The Mast Cell Master”